Journal article

Cellular and molecular mechanisms underlying age-related skeletal muscle wasting and weakness

JG Ryall, JD Schertzer, GS Lynch

Biogerontology | SPRINGER | Published : 2008

DOI: 10.1007/s10522-008-9131-0

Abstract

Some of the most serious consequences of ageing are its effects on skeletal muscle. The term 'sarcopenia' describes the slow but progressive loss of muscle mass with advancing age and is characterised by a deterioration of muscle quantity and quality leading to a gradual slowing of movement and a decline in strength. The loss of muscle mass and strength is thought to be attributed to the progressive atrophy and loss of individual muscle fibres associated with the loss of motor units, and a concomitant reduction in muscle 'quality' due to the infiltration of fat and other non-contractile material. These age-related changes in skeletal muscle can be largely attributed to the complex interactio..

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University of Melbourne Researchers

Gordon Lynch Author

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Keywords

Dystrophic Mdx Mice

3208 Medical Physiology

Myogenic Regulatory Factors

Geriatrics & Gerontology

Myogenin Protein Expression

Sarcoplasmic-Reticulum

Life Sciences & Biomedicine

Musculoskeletal

Growth-Factor-I

Necrosis-Factor-Alpha

Satellite Cells

Igf-Binding Protein-3

Science & Technology

2.1 Biological and Endogenous Factors

32 Biomedical and Clinical Sciences